Controlled Trial of Phenobarbitone in Neonatal Jaundice

Phenobarbitone in neonatal jaundice.

Sinniah, D., Tay, L. K., and Dugdale, A. E. (1971). Archives of Disease in Childhood, 46, 712. Phenobarbitone in neonatal jaundice. Eighty-three jaundiced newborn infants were studied, 41 received phenobarbitone, and 42 served as controls. 48 hours after starting treatment the mean serum bilirubin level of the group of normal birthweight infants was significantly lower than that of controls. Ex...

Relative roles of phototherapy and phenobarbitone in treatment of nonhaemolytic neonatal jaundice.

Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial.

OBJECTIVE To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates. DESIGN Open labeled randomized controlled trial. SETTING Neonatal intensive care unit of a level II unit from India, from November 2008 to September 2009. PARTICIPANTS All term and late pre-term neonates admitted with clinically apparent seizures and not hav...

Phenobarbitone in Neonatal Seizures: Controversies

Seizures are defined clinically as a paroxysmal alteration in neurologic function, i.e., motor, behaviour and/or autonomic function. Seizures are the most important signal of neurological disease in the neonatal period. They occur in 1-5% of the new-borns. The incidence is higher during this period than in any other period in life. It is important to treat seizures because of the potential adve...

Phenobarbitone dosage in neonatal convulsions.

In order to find the optimal dosage schedule of phenobarbitone for neonatal convulsions, four groups of patients were studied. Twelve infants (group 1) received a mean phenobarbitone dose of 9.5 mg/kg a day given intramuscularly for 3 days followed by 5.8 mg/kg a day given intramuscularly and then orally. Six infants (group 2) received a mean intravenous loading dose of 9.5 mg/kg followed by 6....